Pre-filled syringes of synogel® contain high molecular weight sterile hyaluronic acid. Intra-articular injection of hyaluronic acid is an approved treatment to prevent the progression of osteoarthritis, which is performed by a specialist. Osteoarthritis involves the breakdown of articular cartilage and eventually the involvement of subcutaneous bone, which causes inflammation of the surrounding tissues. This complication may affect any of the joints. The most common joints involved are knee, arm, pelvis and spine. One of the benefits of Synogel® is its long-term effect. With this property, Synogel® can increase the quality of life of patients for one year. Synogel ® injection is usually between 3 and 5 injections per visit, depending on the severity of the injury.


The isotonic solution in the Synogel injection syringe contains hyaluronic acid, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate and injectable water.


Synogel is used therapeutically in reducing pain and movement limitations of joints caused by cartilage degeneration as well as injuries caused by changes in synovial fluid in large joints such as knees and shoulders.


Intravascular injection of Synogel is absolutely contraindicated because it may cause systemic adverse effects.

Synogel administration is contraindicated in patients with the following conditions:

- Patients who have a history of allergy to sodium hyaluronate or its derivative compounds.

- Patients with infection or skin diseases at the injection site.

- Patients whose joint fluid is severely inflamed or infected.

- Patients with systemic bleeding disorders.


If the syringe is damaged or the blister is open, do not inject it separately.

If the product is stored in the refrigerator, bring the product to room temperature before injection.

Synogel is designed as a single dose and only for one injection, if the product is used twice, there is no guarantee for the remaining performance and sterility of the medicine and it may lead to damage and inoculation of infection in the patient's joint.

Do not inject Synogel after the expiration date written on the box or the label of the syringe.

Keep out of reach of children.

Side effects

In rare cases, injection of Synogel may cause sensitivity (allergy) and in very rare cases, it may cause anaphylactic shock.

In case of any of the following allergy symptoms, see a doctor or nurse immediately:

- Skin lesions, itching

- Swelling of the face, lips or tongue

- Cough, shortness of breath

These complications may occur both during and after the injection.

After intra-articular injection of Synogel, symptoms such as pain, swelling, temporary inflammation, feeling of heat or redness in the treated joint may be observed. These symptoms are temporary and are relieved by joint rest or cooling with ice packs. If any of these symptoms are not relieved for up to 4 days or if symptoms other than those mentioned occur, see your doctor.

Side effects are more likely to occur in people with autoimmune or connective tissue disorders.

Use in specific populations

Children: Since the safety of the drug has not been studied in children, the drug should be used with caution.

Pregnant women: The safety of Synogel during pregnancy has not been proven and should be used with caution.

Lactating women: Although its side effects have not been proven during breastfeeding, it is recommended to be used with caution during this period.

Amount and method of consumption

Synogel ready-to-inject syringes should only be injected two to three times by an experienced physician. Depending on the severity of the disease, several joints can be treated at the same time. Due to the molecular weight of the hyaluronic acid in the Synogel syringe, the beneficial effects of a full course of treatment may last up to 36 weeks. The treatment cycle may be repeated with the doctor's opinion.

Packaging and storage conditions

A sterile ready-to-inject syringe containing 32 mg of hyaluronic acid in a sterile package.

Store at a temperature below 30 degrees Celsius and protect from freezing.

Bring the product to room temperature before injection.

Hyaluronic acid is produced naturally in the body and is also found in many tissues, including the eyes, skin, and synovial fluid. Hyaluronic acid plays an important biological role in the body: Joint lubrication is one of the most important roles of hyaluronic acid.

Hyaluronic acid absorbs large amounts of water at low concentrations, which helps prevent joint wear. Hyaluronic acid acts as a cartilage nourishment and is involved in reducing the inflammatory cytokine of osteoarthritis. This product is used not only for patients with osteoarthritis but also for athletes who have been injured due to strenuous activity.

Nikan Teb Kimia Company

As a knowledge-based pharmaceutical company, Nitka is focused on improving patients' lives by identifying, developing and commercializing new products. Our main goal is to produce products based on hyaluronic acid molecule for non-invasive orthopedic treatments.

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