The isotonic solution in the Synogel injection syringe contains hyaluronic acid, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate and injectable water.

Synogel is used therapeutically in reducing pain and movement limitations of joints caused by cartilage degeneration as well as injuries caused by changes in synovial fluid in large joints such as knees and shoulders.

Intravascular injection of Synogel is absolutely contraindicated because it may cause systemic adverse effects.

Synogel administration is contraindicated in patients with the following conditions:

- Patients who have a history of allergy to sodium hyaluronate or its derivative compounds.

- Patients with infection or skin diseases at the injection site.

- Patients whose joint fluid is severely inflamed or infected.

- Patients with systemic bleeding disorders.

If the syringe is damaged or the blister is open, do not inject it separately.

If the product is stored in the refrigerator, bring the product to room temperature before injection.

Synogel is designed as a single dose and only for one injection, if the product is used twice, there is no guarantee for the remaining performance and sterility of the medicine and it may lead to damage and inoculation of infection in the patient's joint.

Do not inject Synogel after the expiration date written on the box or the label of the syringe.

Keep out of reach of children.

In rare cases, injection of Synogel may cause sensitivity (allergy) and in very rare cases, it may cause anaphylactic shock.

In case of any of the following allergy symptoms, see a doctor or nurse immediately:

- Skin lesions, itching

- Swelling of the face, lips or tongue

- Cough, shortness of breath

These complications may occur both during and after the injection.

After intra-articular injection of Synogel, symptoms such as pain, swelling, temporary inflammation, feeling of heat or redness in the treated joint may be observed. These symptoms are temporary and are relieved by joint rest or cooling with ice packs. If any of these symptoms are not relieved for up to 4 days or if symptoms other than those mentioned occur, see your doctor.

Side effects are more likely to occur in people with autoimmune or connective tissue disorders.

Children: Since the safety of the drug has not been studied in children, the drug should be used with caution.

Pregnant women: The safety of Synogel during pregnancy has not been proven and should be used with caution.

Lactating women: Although its side effects have not been proven during breastfeeding, it is recommended to be used with caution during this period.

Synogel ready-to-inject syringes should only be injected two to three times by an experienced physician. Depending on the severity of the disease, several joints can be treated at the same time. Due to the molecular weight of the hyaluronic acid in the Synogel syringe, the beneficial effects of a full course of treatment may last up to 36 weeks. The treatment cycle may be repeated with the doctor's opinion.

A sterile ready-to-inject syringe containing 32 mg of hyaluronic acid in a sterile package.

Store at a temperature below 30 degrees Celsius and protect from freezing.

Bring the product to room temperature before injection.