o Joint fluid may lose its ability to protect the joint
o the space between the joints would be reduced
o Cartilage may become porous and hollow, losing its protective effect on the bones. In the advanced stages of the disease, large parts of the cartilage may be completely destroyed and so the bones may be painfully rubbed against each other.
o Cartilage fractures may cause deformity of the joint, resulting in thick bone ends and bone spurs.
o Parts of the bone or cartilage may also float in the joint space, causing more injury and pain.